Endocrine Abstracts

Background: Toxic adenoma (TA) is a rare cause of hyperthyroidism in children, representing less than 3% of cases, more frequently affecting girls. The risk of malignancy in pediatric autonomous nodules is unknown. Despite current guidelines on the management of TA, published case series reveal discrepancies in medical practice.Case presentation: We report a case of TA in a 7-year old boy, incidentally detected as a palpable mass during examination for l...

Introduction: The association of hyperthyroidism and thyroid cancer (TC) is controversial with prevalences in the literature varying from 1.6 to 32.8%. The aim of this work was to evaluate the prevalence of TC in hyperthyroid patients submitted to surgery and to find differences between the tumors according to the type of hyperthyroidism.Material and methods: retrospective study to evaluate clinical and histopathological data of all hyperthyroid patients...

Background: Alemtuzumab (ALTZ) is a humanised monoclonal anti-CD52 antibody used as effective treatment for relapsing/remitting multiple sclerosis (MS), causing panlymphopenia with subsequent lymphocyte repopulation. Unfortunately, around 40% of patients develop secondary humoral autoimmunity, mainly affecting the thyroid gland. Anti-thyrotropin-receptor (TSHR) autoantibodies (TRAb) can stimulate (TSAb), block (TBAb) or not affect (‘neutral’) TSHR function, with TSAb...

Background: Alemtuzumab (ALTZ) is a humanised monoclonal anti-CD52 antibody used as effective treatment for relapsing/remitting multiple sclerosis (MS), causing panlymphopenia with subsequent lymphocyte repopulation. Unfortunately, around 40% of patients develop secondary humoral autoimmunity, mainly affecting the thyroid gland. Anti-thyrotropin-receptor (TSHR) autoantibodies (TRAb) can stimulate (TSAb), block (TBAb) or not affect (‘neutral’) TSHR function, with TSAb...

Background: Latent autoimmune diabetes in adults (LADA) is a form of autoimmune diabetes with a slower decline of β cell function and distinct features from type 1 and type 2 diabetes. LADA is also a very heterogenic group. Frequently LADA is associated with other autoimmune diseases especially endocrine diseases.Aim: To evaluate prevalence of thyroid autoimmunity (TA) and its impact on cardiovascular risk and metabolic syndrome in LADA patients.</p...

Objective: Thyroid malignancy detected incidentally in patients who underwent surgery for thyrotoxicosis has been reported at different rates. The aim of this study was to investigate the rate of incidental thyroid carcinoma (ITC) in thyrotoxic patients underwent surgery in our institution.Methods: The prevalence of ITC was investigated in patients who underwent surgery for Graves’ disease (GD), toxic adenoma (TA) or toxic multinodular goiter (TMNG)...

Background: Testosterone administration (TA) can improve exercise capacity and glucose metabolism of males patients (pts) with chronic heart failure (CHF). It is not known whether testosterone supplementation benefits only CHF subjects with hypogonadism.Aim: To compare effects of TA in male pts with CHF with and without testosterone deficiency.Methods: Fifty-six males patients (median age 64.2±9.6), ejection fraction (EF) 36&#...

Objective: The purpose of this study was to assess clinical outcomes of patients with toxic adenoma (TA) treated with Radioactive Iodine (RAIT) in a tertiary hospital over a period of 8 years. We also analysed the influence of age, gender, TSH at diagnosis and anti-thyroid drugs (ATD) previous to RAIT on the cure rate.Methods: Retrospective analysis of clinical records of all patients with TA submitted to RAIT between 2008 and 2015. The influence of demo...

Background: Fertility preservation (FP) amongst transgender adolescents (TA) is receiving more attention as individuals are transitioning at younger ages. Parents have a key role at exploring options for their children and are usually the ones responsible for consenting to interventions. Our aim was to explore parent’s attitudes regarding their offspring parenthood goals, FP counselling and perceived barriers to successful gamete banking.Methods: Pa...

Background: The treatment of metastatic castration-resistant prostate cancer (CRPC) remains dependent on Androgen Receptor (AR) mediated signalling, thus understanding all components involved in testosterone signalling in these men is of utmost importance. Recent studies have identified 11-ketotestosterone (11 KT) as a potent androgen receptor (AR) agonist present in humans. However, it is unknown if 11 KT is present at physiologically relevant concentrations in CRPC patients....